PEIR Digital Library – Pathology Education
Instructional Resource
 |
Image #7: Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. This area shows dilated acini forming “microglandular” structures. |
 |
Image #8: Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. This tumor shows round cells with scant cytoplasm, slightly irregular nuclei, and distinct nucleoli. |
 |
Image #9: Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. This tumor shows intense immunostaining for trypsin. Note the trypsin positivity of the normal acinar tissue (left) adjacent to the tumor (right). |
 |
Image #10: 414138 Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. Immunostaining for trypsin labels the apical portion of the tumor cells. |
 |
Image #11: 414139 Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. Immunostaining for CAM 5.2 (cytokeratins 8 and 18) labels all tumor cells. |
 |
Image #12: Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. Immunostaining for synaptophysin labels some tumor cells. |
 |
Image #13: 414142 Type: EM Organ/System: Pancreas Description: Acinar Cell Carcinoma. This electron micrograph shows tumor cells with many pleomorphic and rather small zymogen granules (mean diameter 400 to 500 nm; range 200 to 1000 nm), commonly oriented towards the luminal space. They are round and lack a halo between their homogenous dark-staining contents and the granule membrane (x6340). |
 |
Image #14: 414144 Type: Micro Organ/System: Pancreas Description: Acinar Cell Carcinoma. This area of a cystic acinar cell carcinoma is composed of numerous microsysts of varying size. |
| Images and descriptions from the AFIP Atlas of Tumor Pathology. | |