Acinic Cell Adenocarcinoma
The acinic cell adenocarcinoma occurs mainly in the parotid gland,
but intraoral and submandibular origin are also possible. This
lesion is characterized by a benign histomorphologic picture but
by occasional malignant behavior. These lesions are treated by
surgical excision with a generous margin of normal tissue on the
periphery. They do not tend to metastasize to lymph nodes but
favor bone and lung as metastatic sites. They grow slowly and
generally present with "benign" clinical features.
Acinic Cell Carcinoma Image #1
This photomicrograph illustrates the benign histomorphologic character
of the tumor. It is termed acinic cell because the tumor cells
show a marked similarity to the acinar cells of the normal gland.
They have abundant purple cytoplasm and small dark uniform nuclei.
Although they may appear to be benign microscopically, their clinical
behavior is unpredictable, and even the most innocuous appearing
lesions can metastasize.