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History:
The patient is a 32 year old female presenting with a lump in the
left preauricular area. The mass has been present for 4 months.
Histology:
- composed of large cells resembling normal serous
cells
- abundant finely granular cytoplasm
- some cytoplasmic vacuolization
- clear round spaces visible throughout lesion
- PAS positive cytoplasmic granules
Cytology:
- highly cellular specimen
- numerous single cells, sheets and syncytial groupings
- moderate numbers of loose acinar arrangements
- oval cells with eccentric nuclei and basophilic
granular cytoplasm
- cells in sheets had more centrally placed nuclei
and were polygonal in shape
- ound nuclei showing slight variation in size
- small distinct nucleoli present
- moderate numbers of stripped nuclei present
Diagnosis: Acinic Cell Carcinoma
Acinic cell carcinoma (ACC) is an uncommon low-grade malignancy
of the salivary gland , comprising 2-3% of all salivary gland tumors
with up to 90% of these lesions arising the parotid gland. They
occur twice as frequently in women as in men, affecting primarily
middle aged or elderly patients.
References:
Cajulis RS, Gokaslan ST, Yu GH, Frias-Hidvegi D: Fine needle aspiration
biopsy of the salivary gland. A five-year experience with emphasis
on diagnostic pitfalls . Acta Cytol 1997;41: 1412-1420
Cawson RA, Eveson JW: Tumors of the salivary glands. In Diagnostic
Histopathology of Tumors (Vol. I). Edited by CDM Fletcher, Churchill
Livinstone, 1995, pp172
Kini SR, Color atlas of differential diagnosis in exfoliative and
aspiration cytopathology. Baltimore, Wiliams & Wilkins, 1999,
pp 298
Nagel H, Laskawi R, Buter JJ, Schroder M, Shilla R, Droese M: Cytologic
diagnosis of acinic-cell carcinoma of salivary glands. Diagn Cytopathol
1997;16:402-411
Yang GCH, Kuhel WI: Uncommon tumors of the salivary gland in fine
needle aspiration biopsies. A surgeon’s perspective. Acta
Cytol 1997;41:1015-1022
Young, JA: The salivary glands. In Diagnostic Cytopathology. Edited
by W Gray. Hong Kong , Churchill Livingstone, 1995, pp 307-308 |
